CST, 4042S, TCL1 Antibody

Polyclonal Antibody for studying TCL1. Validated for Western Blotting. Highly specific and rigorously validated in-house, TCL1 Antibody (CST #4042) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity TCL1 Antibody detects endogenous levels of total TCL1. Species Reactivity: Human Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of human TCL1. Antibodies are purified by protein A and peptide affinity chromatography. Background T cell leukemia 1 (TCL1), MTCP1, and TCL1b belong to the TCL1 proto-oncogene family, and their products are involved in Akt activation during embryonic development and several types of T-cell leukemias and B-cell lymphomas (1-3). The Akt association domain of TCL1 binds with the PH domain of Akt. The formation of an oligomeric TCL-Akt complex is required for TCL1 coactivator function and results in phosphorylation and activation of Akt. Furthermore, functional analysis indicates that the interaction between TCL1 and Akt promotes translocation of Akt to the nucleus (4-6). These findings are supported by the crystal structure of TCL1, which suggests that TCL1 may participate in molecular transport (7). Alternate Names Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1; T cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma protein 1A; T-cell lymphoma-1; T-cell lymphoma-1A; TCL1; TCL1 family AKT coactivator A; TCL1A Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 14 SOURCE: Rabbit