CST, 44150T, SYNGR3 (E2R8R) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying SYNGR3. Validated for Western Blotting,Immunofluorescence (Frozen),Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, SYNGR3 (E2R8R) Rabbit Monoclonal Antibody (CST #44150) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunofluorescence (Frozen): 1:400 - 1:800 Immunofluorescence (Immunocytochemistry): 1:800 - 1:1600 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 29745 . Protocol Available protocols: Western Blotting, Immunofluorescence (Frozen), Immunofluorescence (Immunocytochemistry) Specificity / Sensitivity SYNGR3 (E2R8R) Rabbit Monoclonal Antibody recognizes endogenous levels of total SYNGR3 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human SYNGR3 protein. Background Synaptogyrin, or SYNGR, are a family of tyrosine-phosphorylated proteins, including neuronal SYNGR1 and SYNGR3 that are found in synaptic vesicles and contribute to the proper synapse function. Synaptogyrin-2 (SYNGR2) expresses ubiquitously and it is not only associated with synaptic vesicles, but also plays an important role in exocytosis processes (1,3). In addition, it has been shown that SYNGRs modulate calcium currents in excitable cells during potassium chloride-dependent exocytosis (3). SYNGR3 and SYNGR1 specifically localize in synaptic vesicles. SYNGR1 modulates synaptic vesicle function similar to SYNGR3 (2,3). SYNGR1 and SYNGR3 contribute to the neurotransmitter release in neurons by interactions with the GABA and VGLUT transporters in primary neurons and in C. elegans (4-6). SYNGRs are associated with disease including Schizophrenia (7,8) and Alzheimer's disease (9,10). Alternate Names MGC:20003; SNG3; synaptogyrin 3; Synaptogyrin-3; SYNGR3 Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 26 Source/Isotype: Rabbit IgG