CST, 73741T, Fc-gammaRIV (E8I7C) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying FCGR4 mouse. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, Fc-gammaRIV (E8I7C) Rabbit Monoclonal Antibody (CST #73741) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunohistochemistry (Paraffin): 1:100 - 1:400 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunohistochemistry (Paraffin) Specificity / Sensitivity Fc-gammaRIV (E8I7C) Rabbit Monoclonal Antibody recognizes endogenous levels of total mouse FcγRIV protein. This antibody does not cross-react with mouse FcγRIA, FcγRIIA, or FcγRIIB. Non-specific staining was observed in adipose tissue by immunohistochemistry. Species Reactivity: Mouse Source / Purification Monoclonal antibody is produced by immunizing animals with mouse FcγRIV recombinant protein. Background FcγRIV is an activating Fcγ receptor present in mice but not humans (2). Binding of Fc receptors to IgG, immune complexes, and opsonized particles results in immune cell activation and effector responses (2). FcγRIV is expressed by myeloid cells and binds to IgG2a and IgG2b, but not to IgG1 or IgG3 (1). FcγRIV signals through ITAM-containing FcRγ (2). Alternate Names 4833442P21Rik; CD16-2; Fc fragment of IgG, low affinity III, receptor for (CD16); Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc gammaRIV; Fc receptor-like 3; Fc receptor, IgG, low affinity IV; Fcgam; FcgammaRIV; Fcgr; Fcgr3a; Fcgr4; FcgRIV; Fcrl3; Low affinity immunoglobulin gamma Fc region receptor III-A; Low affinity immunoglobulin gamma Fc region receptor IV; OTTMUSP00000024985 Specification REACTIVITY: M SENSITIVITY: Endogenous MW (kDa): 30-40 Source/Isotype: Rabbit IgG