Proteintech, 12240-1-AP, DYRK1B Polyclonal antibody

Size: 20ul / 150ul The DYRK1B (12240-1-AP) by Proteintech is a Polyclonal antibody targeting DYRK1B in WB, ELISA applications with reactivity to human, mouse, rat samples 12240-1-AP targets DYRK1B in WB, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Applications Positive WB detected in: mouse testis tissue, HeLa cells, human colon tissue, human heart tissue, mouse skeletal muscle tissue Recommended dilution Western Blot (WB): WB : 1:1000-1:4000 Background Information DYRK1B(dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B) is also named as MIRK. It is a member of the dyrk/minibrain family of serine/threonine kinases that mediate the transition from growth to differentiation in lower eukaryotes and mammals(PMID:15546868). DYRK1B functions as a transcriptional coactivator that is activated by co-expressed MKK3, a MAP kinase that also can activate p38 MAP kinase(PMID:14500717). The DYRK1B splice variants found in each muscle tissue exhibit approximate molecular weights of 70 and 75 kDa(PMID:12902328). It has 3 isoforms produced by alternative splicing of the molecular weight of 65-69 kDa. Specification Tested Reactivity: human, mouse, rat Cited Reactivity: human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag2883 Product name: Recombinant human DYRK1B protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 38-343 aa of BC018751 Sequence: RDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKA Predict reactive species Full Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B Calculated Molecular Weight: 629 aa, 69 kDa Observed Molecular Weight: 57 kDa GenBank Accession Number: BC018751 Gene Symbol: DYRK1B Gene ID (NCBI): 9149 RRID: AB_2093803 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q9Y463 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.