Proteintech, 12950-1-AP, TMPRSS6 Polyclonal antibody

Size: 20ul / 150ul The TMPRSS6 (12950-1-AP) by Proteintech is a Polyclonal antibody targeting TMPRSS6 in WB, ELISA applications with reactivity to human, mouse, rat samples 12950-1-AP targets TMPRSS6 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Applications Positive WB detected in: HEK-293 cells, HepG2 cells, MCF-7 cells, mouse liver tissue Recommended dilution Western Blot (WB): WB : 1:500-1:1000 Background Information The type II transmembrane serine protease TMPRSS6 (also known as matriptase-2) controls iron homeostasis through its negative regulation of expression of hepcidin, a key hormone involved in iron metabolism. Upstream of the hepcidin-regulated signaling pathway, TMPRSS6 cleaves its target substrate hemojuvelin (HJV) at the plasma membrane(PMID:21724843).It Belongs to the peptidase S1 family.Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA).It has 4 isoforms produced by alternative splicing. Specification Tested Reactivity: human, mouse, rat Cited Reactivity: human, mouse Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag4076 Product name: Recombinant human TMPRSS6 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 76-375 aa of BC039082 Sequence: LGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELLSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVEVLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYYSPQTHCSWHLTVPSL Predict reactive species Full Name: transmembrane protease, serine 6 Calculated Molecular Weight: 89 kDa Observed Molecular Weight: 52 kDa GenBank Accession Number: BC039082 Gene Symbol: TMPRSS6 Gene ID (NCBI): 164656 RRID: AB_2877896 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q8IU80 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.