Proteintech, 13964-1-AP, Siglec-12 Polyclonal antibody

Size: 20ul / 150ul The Siglec-12 (13964-1-AP) by Proteintech is a Polyclonal antibody targeting Siglec-12 in WB, ELISA applications with reactivity to human, mouse, rat, pig samples 13964-1-AP targets Siglec-12 in WB, ELISA applications and shows reactivity with human, mouse, rat, pig samples. Tested Applications Positive WB detected in: mouse spleen tissue, rat spleen tissue, pig spleen tissue Recommended dilution Western Blot (WB): WB : 1:500-1:1000 Background Information Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily that contain sialoside-binding N-terminal domains (PMID: 22749793). Sialic acid binding Ig-like lectin 12 (Siglec-12, also known as S2V, SLG, SIGLECL1, and Siglec-XII) is a member of the SIGLEC3-like subfamily of SIGLECs, which is highly expressed in the spleen, such as CD8+ cells, macrophages, neutrophils, and dendritic cells. It mediates sialic-acid-dependent binding to cells and could be an identification of therapeutic targets and prognostic biomarkers of sarcomas (PMID: 38182638). Specification Tested Reactivity: human, mouse, rat, pig Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag4939 Product name: Recombinant human SIGLEC12 protein Source: e coli. -derived, T-HIS Tag: 6*His Domain: 22-350 aa of BC035809 Sequence: KDYLLTMQKSVTVQEGLCVSVLCSFSYPQNGWTASDPVHGYWFRAGDHVSRNIPVATNNPARAVQEETRDRFHLLGDPQNKDCTLSIRDTRESDAGTYVFCVERGNMKWNYKYDQLSVNVTASQDLLSRYRLEVPESVTVQEGLCVSVPCSVLYPHYNWTASSPVYGSWFKEGADIPWDIPVATNTPSGKVQEDTHGRFLLLGDPQTNNCSLSIRDARKGDSGKYYFQVERGSRKWNYIYDKLSVHVTALTHMPTFSIPGTLESGHPRNLTCSVPWACEQGTPPTITWMGASVSSLDPTITRSSMLSLIPQPQDHGTSLTCQVTLPGAG Predict reactive species Full Name: sialic acid binding Ig-like lectin 12 Calculated Molecular Weight: 595 aa, 65 kDa Observed Molecular Weight: 70 kDa GenBank Accession Number: BC035809 Gene Symbol: SIGLEC12 Gene ID (NCBI): 89858 RRID: AB_3669172 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q96PQ1 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.