Proteintech, 22305-1-AP, Amylin Polyclonal antibody

Size: 20ul / 150ul The Amylin (22305-1-AP) by Proteintech is a Polyclonal antibody targeting Amylin in IHC, ELISA applications with reactivity to human, rat, mouse samples 22305-1-AP targets Amylin in IHC, ELISA applications and shows reactivity with human, rat, mouse samples. Tested Applications Positive IHC detected in: human pancreas tissue, mouse pancreas tissue, rat pancreas tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0 Recommended dilution Immunohistochemistry (IHC): IHC : 1:20-1:200 Background Information IAPP, also known as Amylin, is commonly found in pancreatic islets of patients suffering diabetes mellitus type II, or harboring a tumor of the pancreas that is derived from beta cells and secretes INS. IAPP is co-secreted with INS by pancreatic β-cells and largely contributes to glycemic control. Studies suggest that this protein, like the related beta-amyloid (Abeta) associated with Alzheimer's disease, can induce apoptotic cell-death in particular cultured cells, an effect that may be relevant to the development of type II diabetes. Specification Tested Reactivity: human, rat, mouse Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: Peptide Predict reactive species Full Name: islet amyloid polypeptide Calculated Molecular Weight: 10 kDa GenBank Accession Number: NM_000415 Gene Symbol: Amylin Gene ID (NCBI): 3375 RRID: AB_2879067 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen Affinity purified UNIPROT ID: P10997 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.