Proteintech, 24287-1-AP, PDE11A Polyclonal antibody

Size: 20ul / 150ul The PDE11A (24287-1-AP) by Proteintech is a Polyclonal antibody targeting PDE11A in WB, ELISA applications with reactivity to human, mouse, rat samples 24287-1-AP targets PDE11A in WB, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Applications Positive WB detected in: mouse cerebellum tissue, mouse liver tissue, rat liver tissue Recommended dilution Western Blot (WB): WB : 1:500-1:1000 Background Information PDE11A is a dual-specificity cyclic nucleotide phosphodiesterase that regulates cAMP and cGMP signaling in a tissue-restricted manner, with prominent roles in the endocrine system and brain. By shaping compartmentalized second-messenger signaling, PDE11A controls steroidogenesis, neuronal plasticity, and hormone responsiveness. Genetic alterations in PDE11A underlie adrenal hyperplasia, endocrine dysfunction, and neuropsychiatric phenotypes, highlighting its importance in cyclic nucleotide homeostasis. Specification Tested Reactivity: human, mouse, rat Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag16495 Product name: Recombinant human PDE11A protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 582-934 aa of BC114431 Sequence: SYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSSPASVMVAKEDRN Predict reactive species Full Name: phosphodiesterase 11A Calculated Molecular Weight: 934 aa, 105 kDa Observed Molecular Weight: 66 kDa GenBank Accession Number: BC114431 Gene Symbol: PDE11A Gene ID (NCBI): 50940 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q9HCR9 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.