Proteintech, 24532-1-AP, SESN3 Polyclonal antibody

Size: 20ul / 150ul The SESN3 (24532-1-AP) by Proteintech is a Polyclonal antibody targeting SESN3 in WB, ELISA applications with reactivity to human samples 24532-1-AP targets SESN3 in WB, IHC, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: HepG2 cells, A431 cells Recommended dilution Western Blot (WB): WB : 1:500-1:1000 Background Information Sestrins, including sestrin-1 (PA26), sestrin-2 (Hi95), and sestrin-3, are 48 to 65 kDa cystein sulfinyl reductases and they modulate peroxide signaling and antioxidant defense. These proteins selectively reduce or repair hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. Expression of these proteins is regulated by p53, a tumor suppressor protein. Sestrin 3 was identified as a forkhead box O (FoxO) target gene with antioxidant activity. Recently it was reported that sestrin 3 may play an important role in AKT induced increase in ROS and it might be a promising target in selectively killing cancer cells containing high levels of AKT activity. Specification Tested Reactivity: human Cited Reactivity: human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag21380 Product name: Recombinant human SESN3 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 199-262 aa of BC017296 Sequence: HYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLANDNNIENASLSGSNFGIVDSLSEL Predict reactive species Full Name: sestrin 3 Calculated Molecular Weight: 492 aa, 57 kDa Observed Molecular Weight: 57 kDa GenBank Accession Number: BC017296 Gene Symbol: SESN3 Gene ID (NCBI): 143686 RRID: AB_2879593 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: P58005 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.