Proteintech, 28619-1-AP, FANCD2 Polyclonal antibody

Size: 20ul / 150ul The FANCD2 (28619-1-AP) by Proteintech is a Polyclonal antibody targeting FANCD2 in WB, ELISA applications with reactivity to human samples 28619-1-AP targets FANCD2 in WB, IHC, IF, IP, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: HeLa cells, K-562 cells Recommended dilution Western Blot (WB): WB : 1:500-1:2000 Background Information FANCD2, also named as FACD and FACD2, is required for maintenance of chromosomal stability. FANCD2 promotes accurate and efficient pairing of homologs during meiosis. FANCD2 is involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. It may participate in S phase and G2 phase checkpoint activation upon DNA damage. It promotes BRCA2/FANCD1 loading onto damaged chromatin. FANCD2 may also be involved in B-cell immunoglobulin isotype switching. Defects in FANCD2 are a cause of Fanconi anemia (FA) which is a genetically heterogeneous, autosomal recessive disorder characterized by progressive pancytopenia, a diverse assortment of congenital malformations, and a predisposition to the development of malignancies. Specification Tested Reactivity: human Cited Reactivity: human, mouse Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: CatNo: Ag29460 Product name: Recombinant human FANCD2 protein Source: e coli. -derived, PGEX-4T Tag: GST Domain: 1-127 aa of NM_001018115 Sequence: MVSKRRLSKSEDKESLTEDASKTRKQPLSKKTKKSHIANEVEENDSIFVKLLKISGIILKTGESQNQLAVDQIAFQKKLFQTLRRHPSYPKIIEEFVSGLESYIEDEDSFRNCLLSCERLQDEEASM Predict reactive species Full Name: Fanconi anemia, complementation group D2 Calculated Molecular Weight: 164 kDa Observed Molecular Weight: 150 kDa GenBank Accession Number: NM_001018115 Gene Symbol: FANCD2 Gene ID (NCBI): 2177 RRID: AB_2881182 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q9BXW9 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.