Proteintech, 31597-1-AP, Phospho-SAMHD1 (Thr592) Polyclonal antibody

Size: 20ul / 100ul The Phospho-SAMHD1 (Thr592) (31597-1-AP) by Proteintech is a Polyclonal antibody targeting Phospho-SAMHD1 (Thr592) in WB, ELISA applications with reactivity to human samples 31597-1-AP targets Phospho-SAMHD1 (Thr592) in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: THP-1 cells, λ phosphatase treated THP-1 cells Recommended dilution Western Blot (WB): WB : 1:500-1:2000 Background Information SAMHD1 is a GTP/dGTP-activated deoxynucleotide triphosphohydrolase. Human SAMHD1 is a 626 amino acid protein comprising an N-terminal nuclear localisation signal, two major structural domains. SAMHD1 has been reported to have alternative nuclease and/or RNA binding activities that, dependent on the cellular circumstances, can also mediate restriction of HIV-1. In addition, restriction is regulated by Threonine 592 phosphorylation and removing this regulation may enable SAMHD1 to inhibit HIV-1 in cycling cells. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: Peptide Predict reactive species Full Name: SAM domain and HD domain 1 Calculated Molecular Weight: 626 aa, 72 kDa Observed Molecular Weight: 72 kDa GenBank Accession Number: BC036450 Gene Symbol: SAMHD1 Gene ID (NCBI): 25939 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q9Y3Z3 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.