Proteintech, 65055-1-Ig, Anti-Mouse CD11b (M1/70)

Size: 500ug The CD11b (65055-1-Ig) by Proteintech is a Monoclonal antibody targeting CD11b in FC applications with reactivity to human, mouse, rabbit, monkey, guinea pig, non-human primates samples 65055-1-Ig targets CD11b in IF, FC applications and shows reactivity with human, mouse, rabbit, monkey, guinea pig, non-human primates samples. Tested Applications Positive FC detected in: mouse bone marrow cells Recommended dilution Flow Cytometry (FC): FC : 0.2 ug per 10^6 cells in 100 μl suspension Background Information Integrins are cell adhesion receptors that are heterodimers composed of non-covalently associated α and β subunits (PMID: 9779984). CD11b, also known as Integrin alpha M or CR3A, belongs to the integrin alpha chain family. CD11b forms an α/β heterodimer with CD18 (integrin β2). CD11b/CD18 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens (PMID: 9558116; 20008295). CD11b/CD18 is a receptor for the complement protein fragment iC3b, and is also a receptor for fibrinogen, factor X and ICAM1 (PMID: 2971974; 15485828). Specification Tested Reactivity: human, mouse, rabbit, monkey, guinea pig, non-human primates Cited Reactivity: mouse Host / Isotype: Rat / IgG2b, kappa Class: Monoclonal Type: Antibody Immunogen: C57BL/10 mouse splenic T cells and concanavalin A-activated C57BL/10 splenocytes Predict reactive species Full Name: integrin alpha M Calculated Molecular Weight: 127 kDa GenBank Accession Number: BC156991 Gene Symbol: CD11b Gene ID (NCBI): 16409 RRID: AB_2918363 Conjugate: Unconjugated Form: Liquid Purification Method: Protein G purification UNIPROT ID: E9Q604 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.