Proteintech, 65058-1-Ig, Anti-Mouse CD31 (390)

Size: 100ug / 500ug The CD31 (65058-1-Ig) by Proteintech is a Monoclonal antibody targeting CD31 in IF/ICC, FC applications with reactivity to mouse samples 65058-1-Ig targets CD31 in IF/ICC, FC applications and shows reactivity with mouse samples. Tested Applications Positive IF/ICC detected in: bEnd.3 cells Positive FC detected in: mouse splenocytes Recommended dilution Immunofluorescence (IF)/ICC: IF/ICC : 1:50-1:500 Flow Cytometry (FC): FC : 0.5 ug per 10^6 cells in 100 μl suspension Background Information Platelet endothelial cell adhesion molecule-1 (PECAM-1, CD31) is a member of the immunoglobulin gene superfamily of cell adhesion molecules. CD31 is a transmembrane glycoprotein that is highly expressed on the surface of the endothelium, making up a large portion of its intracellular junctions. PECAM-1 is also present on the surface of hematopoietic cells and immune cells including platelets, monocytes, neutrophils, natural killer cells, megakaryocytes and some types of T-cell (PMID: 9011572). As well as its role in cell-cell adhesion, PECAM-1 functions as a signaling receptor, and is involved in important physiological events such as nitric oxide production, regulation of T-cell immunity and tolerance, leukocyte transendothelial migration and inflammation and angiogenesis (PMID: 21183735; 20978210; 17872453; 20634489). Specification Tested Reactivity: mouse Cited Reactivity: mouse Host / Isotype: Rat / IgG2a, kappa Class: Monoclonal Type: Antibody Immunogen: C3H/HeJ mouse hematopoietic progenitor cell line 32D Predict reactive species Full Name: platelet/endothelial cell adhesion molecule 1 GenBank Accession Number: BC008519 Gene Symbol: CD31 Gene ID (NCBI): 18613 RRID: AB_2918366 Conjugate: Unconjugated Form: Liquid Purification Method: Affinity purification UNIPROT ID: Q08481 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.