Proteintech, 65063-1-Ig, Anti-Human CD44 (F10-44-2)

Size: 100ug / 500ug The CD44 (65063-1-Ig) by Proteintech is a Monoclonal antibody targeting CD44 in FC applications with reactivity to Human samples 65063-1-Ig targets CD44 in FC applications and shows reactivity with Human samples. Tested Applications Positive FC detected in: human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.2 ug per 10^6 cells in 100 μl suspension Background Information CD44 is a type I transmembrane glycoprotein expressed on embryonic stem cells and in various levels on other cell types including connective tissues and bone marrow. CD44 expression is also upregulated in subpopulations of cancer cells and is recognized as a molecular marker for cancer stem cells (PMID: 29747682). It is a cell-surface receptor that mediates cell-cell and cell-matrix interactions through its affinity for hyaluronic acid (HA) and possibly also through its affinity for other ligands (PMID: 10694938). Adhesion with HA plays an important role in cell migration, tumor growth and progression. CD44 is also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Specification Tested Reactivity: Human Cited Reactivity: human Host / Isotype: Mouse / IgG2a, kappa Class: Monoclonal Type: Antibody Immunogen: Purified T cells from human lymph nodes Predict reactive species Full Name: CD44 molecule (Indian blood group) Calculated Molecular Weight: 742 aa, 82 kDa GenBank Accession Number: BC004372 Gene Symbol: CD44 Gene ID (NCBI): 960 ENSEMBL Gene ID: ENSG00000026508 RRID: AB_2918370 Conjugate: Unconjugated Form: Liquid Purification Method: Affinity purification UNIPROT ID: P16070 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.