Proteintech, 65102-1-Ig, Anti-Mouse GITR/TNFRSF18 (DTA-1)

Size: 100ug / 500ug The GITR/TNFRSF18 (65102-1-Ig) by Proteintech is a Monoclonal antibody targeting GITR/TNFRSF18 in FC applications with reactivity to mouse samples 65102-1-Ig targets GITR/TNFRSF18 in FC applications and shows reactivity with mouse samples. Tested Applications Positive FC detected in: mouse splenocytes Recommended dilution Flow Cytometry (FC): FC : 0.5 ug per 10^6 cells in 100 μl suspension Background Information Glucocorticoid-induced TNFR-related protein (GITR), also known as CD357 or TNFRSF18, is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is expressed constitutively at high levels in T regulatory cells (Treg cells) and plays a key role in dominant immunological self-tolerance maintained by CD25+CD4+ regulatory T cells (PMID: 11812990). It is expressed at low levels on resting responder T cells. The expression of GITR on T cells can be upregulated upon activation (PMID: 15770698). GITR is activated by GITR ligand (GITRL) which is mainly expressed on APC. GITR-GITRL interactions could co-stimulate both responder T-cell functions and the suppressive functions of Treg cells (PMID: 16868552). Specification Tested Reactivity: mouse Host / Isotype: Rat / IgG2b, kappa Class: Monoclonal Type: Antibody Immunogen: Mouse CD25+ CD4+ T cells Predict reactive species Full Name: tumor necrosis factor receptor superfamily, member 18 GenBank Accession Number: BC146517 Gene Symbol: CD357 Gene ID (NCBI): 21936 RRID: AB_2918402 Conjugate: Unconjugated Form: Liquid Purification Method: Affinity purification UNIPROT ID: O35714 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.