Proteintech, 65155-1-Ig, Anti-Human CD206 (15-2)

Size: 100ug The CD206 (65155-1-Ig) by Proteintech is a Monoclonal antibody targeting CD206 in FC applications with reactivity to human samples 65155-1-Ig targets CD206 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: GM-CSF treated human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information CD206, also named as MMR, CLEC13D and MRC1, is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region, a fibronectin type II repeat, a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose), a transmembrane domain, and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages, in vitro derived dendritic cells, lymphatic and sinusoidal endothelia. Specification Tested Reactivity: human Host / Isotype: Mouse / IgG1, kappa Class: Monoclonal Type: Antibody Immunogen: Purified human mannose receptor Predict reactive species Full Name: mannose receptor, C type 1 Calculated Molecular Weight: 166 kDa GenBank Accession Number: NM_002438 Gene Symbol: CD206 Gene ID (NCBI): 4360 RRID: AB_2918437 Conjugate: Unconjugated Form: Liquid Purification Method: Purified by protein-A affinity chromatography UNIPROT ID: P22897 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.