Proteintech, 65221-1-Ig, Anti-Mouse B7-H3/CD276 (MJ18)

Size: 100ug / 500ug The B7-H3/CD276 (65221-1-Ig) by Proteintech is a Monoclonal antibody targeting B7-H3/CD276 in FC applications with reactivity to mouse samples 65221-1-Ig targets B7-H3/CD276 in FC applications and shows reactivity with mouse samples. Tested Applications Positive FC detected in: mouse peritoneal macrophages Recommended dilution Flow Cytometry (FC): FC : 1 ug per 10^6 cells in 100 μl suspension Background Information CD276 (also known as B7-H3) is a type I transmembrane protein expressed on many tissues and cell types. CD276 is a 100-kDa glycoprotein that belongs to the B7 immunoregulatory family and participates in the regulation of T-cell-mediated immune response probably by functioning as both a T cell costimulator and coinhibitor (PMID: 25567370; 20696859). Overexpressed on a wide range of human solid cancers, CD276 has been implicated in cancer progression and metastasis and becomes an attractive target for cancer immunotherapy (PMID: 27208063). Specification Tested Reactivity: mouse Host / Isotype: Rat / IgG1, kappa Class: Monoclonal Type: Antibody Immunogen: Mouse IgG2a Fc-CD276 (aa 1-242) fusion protein Predict reactive species Full Name: CD276 antigen GenBank Accession Number: BC019436 Gene Symbol: Cd276 Gene ID (NCBI): 102657 RRID: AB_2935144 Conjugate: Unconjugated Form: Liquid Purification Method: Protein G purification UNIPROT ID: Q8VE98 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.