Proteintech, 66464-1-Ig, ADRM1 Monoclonal antibody

Size: 20ul / 150ul The ADRM1 (66464-1-Ig) by Proteintech is a Monoclonal antibody targeting ADRM1 in WB, IF/ICC, ELISA applications with reactivity to human samples 66464-1-Ig targets ADRM1 in WB, IF/ICC, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: HeLa cells, HEK-293 cells, Raji cells Positive IF/ICC detected in: HeLa cells Recommended dilution Western Blot (WB): WB : 1:5000-1:20000 Immunofluorescence (IF)/ICC: IF/ICC : 1:200-1:800 Background Information The 26S proteasome is a key component of the ubiquitin-proteasome system, a process responsible for the majority of cellular protein degradation. hRpn13 (also termed ADRM1 or GP110) is a novel 46-kDa subunit of its 19S regulatory complex. hRpn13 binds directly to the proteasome-associated deubiquitinating enzyme, UCH37, and enhances its isopeptidase activity. Overexpression of hRpn13 promotes the activity of the ubiquitin-proteasome system and modulates the influence of osteoblasts on osteoclasts by controlling the stability of regulatory proteins in osteoblasts. Specification Tested Reactivity: human Host / Isotype: Mouse / IgG3 Class: Monoclonal Type: Antibody Immunogen: CatNo: Ag24699 Product name: Recombinant human ADRM1 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-407 aa of BC017245 Sequence: MTTSGALFPSLVPGSRGASNKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGNVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNEYLNNPPMPGALGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPGSSSSSSSRSQSAAVTPSSTTSSTRATPAPSAPAAASATSPSPAPSSGNGASTAASPTQPIQLSDLQSILATMNVPAGPAGGQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTADEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKPEQKEGDTKDKKDEEEDMSLD Predict reactive species Full Name: adhesion regulating molecule 1 Calculated Molecular Weight: 407 aa, 42 kDa Observed Molecular Weight: 42 kDa GenBank Accession Number: BC017245 Gene Symbol: ADRM1 Gene ID (NCBI): 11047 RRID: AB_2881832 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q16186 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.