Proteintech, 67510-1-Ig, SIRT6 Monoclonal antibody

Size: 20ul / 150ul The SIRT6 (67510-1-Ig) by Proteintech is a Monoclonal antibody targeting SIRT6 in WB, ELISA applications with reactivity to human, mouse samples 67510-1-Ig targets SIRT6 in WB, CoIP, ELISA applications and shows reactivity with human, mouse samples. Tested Applications Positive WB detected in: JAR cells, Jurkat cells, NCCIT cells, LNCaP cells, HeLa cells, K-562 cells, HL-60 cells. Recommended dilution Western Blot (WB): WB : 1:2000-1:10000 Background Information SIRT6, also named as SIR2L6, belongs to the sirtuin family. It is known to deacetylate H3K9, H3K56 and CtIP in vivo. SIRT6 regulates the expression of a large number of stress-responsive and metabolism related genes, promotes genomic stability and stimulates base excision and double strand break DNA repair(PMID: 20729089). By maintaining both the integrity and the expression of the mammalian genome, SIRT6 thus serves several roles that parallel Sir2 function(PMID: 20729089). In addtion, Sirt6-deficient animals develop normally for several weeks after birth, but succumb to an acute multi-organ degenerative syndrome that is uniformly lethal by one month of age(PMID: 19135889). Specification Tested Reactivity: human, mouse Cited Reactivity: human, mouse Host / Isotype: Mouse / IgG1 Class: Monoclonal Type: Antibody Immunogen: CatNo: Ag24103 Product name: Recombinant human SIRT6 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 1-328 aa of BC028220 Sequence: MSVNYAAGLSPYADKGKCGLPEIFDPPEELERKVWELARLVWQSSNVVFHTGAGISTASGIPDFRGPHGVWTMEERGLAPKFDTTFESARPTQTHMALVQLERVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECAKCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVMTRLMKHLGLEIPAWDGPRVLERALPPLPRPPTPKLEPKEESPTRINGSIPAGPKQEPCAQHNGSEPASPKRERPTSPAPHRPPKRVKAKAVPS Predict reactive species Full Name: sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) Calculated Molecular Weight: 39 kDa Observed Molecular Weight: 40 kDa GenBank Accession Number: BC028220 Gene Symbol: SIRT6 Gene ID (NCBI): 51548 RRID: AB_2882731 Conjugate: Unconjugated Form: Liquid Purification Method: Protein G purification UNIPROT ID: Q8N6T7 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.