Proteintech, 69018-1-Ig, NeutraKine® IL-10 Mouse McAb

Size: 25ug / 100ug The NeutraKine® IL-10 (69018-1-Ig) by Proteintech is a Monoclonal antibody targeting NeutraKine® IL-10 in IHC, Neutralization, ELISA applications with reactivity to human samples 69018-1-Ig targets NeutraKine® IL-10 in IHC, IF, Neutralization, ELISA applications and shows reactivity with human samples. Background Information Interleukin (IL)-10 is an anti-inflammatory cytokine, produced by T helper (Th) cells, macrophages, monocytes, and B cells, that plays a crucial role in preventing inflammatory and autoimmune pathologies. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10, along with its receptors, describes an important role in pathogenesis of various diseases, including infectious, inflammatory, autoimmune diseases. IL-10 mutations are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis.This antibody can be used to neutralize the bioactivity of IL-10. Specification Tested Reactivity: human Cited Reactivity: human, mouse Host / Isotype: Mouse / IgG1 Class: Monoclonal Type: Antibody Immunogen: CatNo: Product name: HumanKine® recombinant human IL-10 protein Source: -derived, Tag: Domain: of Sequence: Predict reactive species Full Name: interleukin 10 Gene Symbol: IL-10 Gene ID (NCBI): 3586 RRID: AB_2918838 Conjugate: Unconjugated Form: Lyophilized Powder Purification Method: Protein G purification UNIPROT ID: P22301 Storage Buffer: Sterile PBS, pH 7.4. Endotoxin: <0.1 EU/μg Reconstitution: This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. Stability and Storage: Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.