Proteintech, 69021-1-Ig, NeutraKine® IL-17A Mouse McAb

Size: 25ug / 100ug The NeutraKine® IL-17A (69021-1-Ig) by Proteintech is a Monoclonal antibody targeting NeutraKine® IL-17A in Neutralization, ELISA applications with reactivity to human samples 69021-1-Ig targets NeutraKine® IL-17A in Neutralization, ELISA, Cell treatment applications and shows reactivity with human samples. Background Information IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased.This antibody can be used to neutralize the bioactivity of IL-17A. Specification Tested Reactivity: human Cited Reactivity: human Host / Isotype: Mouse / IgG1 Class: Monoclonal Type: Antibody Immunogen: Recombinant Protein Predict reactive species Full Name: interleukin 17A Gene Symbol: IL-17A Gene ID (NCBI): 3605 ENSEMBL Gene ID: ENSG00000112115 RRID: AB_2918841 Conjugate: Unconjugated Form: Lyophilized Powder Purification Method: Protein G purification UNIPROT ID: Q16552 Storage Buffer: Sterile PBS, pH 7.4. Endotoxin: <0.1 EU/μg Reconstitution: This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. Stability and Storage: Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.