Proteintech, 84600-5-RR, KIM-1/HAVCR1 Recombinant monoclonal antibody

Size: 20ul / 100ul The KIM-1/HAVCR1 (84600-5-RR) by Proteintech is a Recombinant antibody targeting KIM-1/HAVCR1 in WB, ELISA applications with reactivity to human samples 84600-5-RR targets KIM-1/HAVCR1 in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: HuH-7 cells Recommended dilution Western Blot (WB): WB : 1:1000-1:6000 Background Information TIM-1, also known as kidney injury molecule (KIM-1), was first identified as a marker of acute kidney injury. TIM-1 mRNA and protein dramatically increase after ischemic kidney injury while there are low levels in normal kidneys. In addition, TIM-1 is expressed on CD4+ T cells after activation and its expression was sustained preferentially in Th2 but not Th1 cells. However, TIM-1 is expressed on both Th1 and Th2 cells and TIM-1 blockade prolongs survival of fully MHC-mismatched cardiac transplants. TIM-4, expressed by macrophages, is the ligand for TIM-1, and TIM-1 - TIM-4 interactions regulate Th cell responses and modulate Th1/Th2 cytokine balance. Moreover, TIM-1 can regulate macrophage activation and alter the co-stimulatory properties of macrophages. (PMID: 20091883) Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: CatNo: Eg1442 Product name: Recombinant Human KIM-1/HAVCR1 protein (rFc Tag) Source: mammalian cells -derived, pHZ-KIsec-C-rFc Tag: C-rFc Domain: 21-295 aa of NM_001173393.3 Sequence: SVKVGGEAGPSVTLPCHYSGAVTSMCWNRGSCSLFTCQNGIVWTNGTHVTYRKDTRYKLLGDLSRRDVSLTIENTAVSDSGVYCCRVEHRGWFNDMKITVSLEIVPPKVTTTPIVTTVPTVTTVRTSTTVPTTTTVPMTTVPTTTVPTTMSIPTTTTVLTTMTVSTTTSVPTTTSIPTTTSVPVTTTVSTFVPPMPLPRQNHEPVATSPSSPQPAETHPTTLQGAIRREPTSSPLYSYTTDGNDTVTESSDGLWNNNQTQLFLEHSLLTANTTKG Predict reactive species Full Name: hepatitis A virus cellular receptor 1 Calculated Molecular Weight: 39kDa Observed Molecular Weight: 100 kDa GenBank Accession Number: NM_001173393.3 Gene Symbol: HAVCR1 Gene ID (NCBI): 26762 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: Q96D42 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.