Proteintech, 85104-3-RR, Cleaved Caspase 10/P23 Recombinant monoclonal antibody

Size: 20ul / 100ul The Cleaved Caspase 10/P23 (85104-3-RR) by Proteintech is a Recombinant antibody targeting Cleaved Caspase 10/P23 in WB, ELISA applications with reactivity to human samples 85104-3-RR targets Cleaved Caspase 10/P23 in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: Staurosporine treated Jurkat cells Recommended dilution Western Blot (WB): WB : 1:1000-1:4000 Background Information CASP10(Caspase-10) is also named as MCH4 and belongs to the peptidase C14A family. It is recruited to the CD99 and p55 tumor necrosis factor receptor signaling complexes and promoting CD95 (APO1/Fas) apoptosis. It may also play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria(PMID:21103379). This protein can be Cleavage by granzyme B and autocatalytic activity generate two active subunits. Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A)(PMID:16446975), familial non-Hodgkin lymphoma (NHL)(PMID:12010812) and gastric cancer (GASC)(PMID:11973654). This antibody recognize the cleaved caspase 10. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: caspase 10, apoptosis-related cysteine peptidase Calculated Molecular Weight: 59 kDa Observed Molecular Weight: 23 kDa GenBank Accession Number: BC042844 Gene Symbol: Caspase 10 Gene ID (NCBI): 843 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: Q92851 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.