Proteintech, 85740-1-RR, SCN11A Recombinant monoclonal antibody

Size: 20ul / 100ul The SCN11A (85740-1-RR) by Proteintech is a Recombinant antibody targeting SCN11A in WB, IHC, ELISA applications with reactivity to human, mouse, rat samples 85740-1-RR targets SCN11A in WB, IHC, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Applications Positive WB detected in: rat brain tissue, rat cerebellum tissue Positive IHC detected in: rat cerebellum tissue, mouse brain tissue, rat brain tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0 Recommended dilution Western Blot (WB): WB : 1:500-1:2000 Immunohistochemistry (IHC): IHC : 1:1500-1:6000 Background Information Sodium channel protein type 11 subunit alpha (SCN11A, also known as Nav1.9) is crucial for generating action potentials and regulating neuronal excitability, particularly in nociceptive neurons of the dorsal root ganglia (DRG) and trigeminal ganglia (PMID: 33752606). Nav1.9 channels are involved in the formation of pain-sensing and have been implicated in peripheral inflammatory pain hypersensitivity. Additionally, SCN11A-mediated channels play a role in regulating colonic motility and neurotransmitter release in the enteric nervous system (PMID: 35711274). Specification Tested Reactivity: human, mouse, rat Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: sodium channel, voltage-gated, type XI, alpha subunit Calculated Molecular Weight: 205 kDa Observed Molecular Weight: 205 kDa GenBank Accession Number: NM_001349253 Gene Symbol: SCN11A Gene ID (NCBI): 11280 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q9UI33 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.