Proteintech, 86777-1-RR, APP Recombinant monoclonal antibody

Size: 20ul / 100ul The APP (86777-1-RR) by Proteintech is a Recombinant antibody targeting APP in WB, ELISA applications with reactivity to human, mouse, rat samples 86777-1-RR targets APP in WB, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Applications Positive WB detected in: fetal human brain tissue, rat brain tissue, mouse brain tissue, FAD3T mouse brain tissue Recommended dilution Western Blot (WB): WB : 1:1000-1:4000 Background Information Aβ derives from APP via proteolytic cleavage by proteases called α-, β- and γ-secretase. The α-secretase cleavage precludes the formation of Aβ, while the β- and γ-cleavages generate APP components with amyloidogenic features. Amyloid beta A4 precursor protein(APP), encoded by APP gene which locate on human chromosome 21q, is a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. APP expressed in all fetal tissues and is pronounced in brain, kidney, heart and spleen, but weak in liver. Defects in APP are the cause of Alzheimer disease type 1 (AD1). Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms. Specification Tested Reactivity: human, mouse, rat Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: amyloid beta (A4) precursor protein Observed Molecular Weight: 100-140 kDa GenBank Accession Number: BC065529 Gene Symbol: APP Gene ID (NCBI): 351 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P05067 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.