Proteintech, 98023-2-RR, Anti-Human TIGIT Rabbit Recombinant Antibody

Size: 100ug The TIGIT (98023-2-RR) by Proteintech is a Recombinant antibody targeting TIGIT in FC applications with reactivity to human samples 98023-2-RR targets TIGIT in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information TIGIT (T-cell immunoreceptor with Ig and ITIM domains), also known as VSIG9 or VSTM3, is an immune receptor expressed on T cells, including Treg and memory subsets, as well as on NK cells (PMID: 19011627). It contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT binds to poliovirus receptor (PVR, also called CD155) with high affinity, and also to PVRL2 (CD112) with lower affinity. The interaction of TIGIT with PVR on dendritic cells increases the secretion of IL-10 and decreases the secretion of proinflammatory cytokine and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. TIGIT can inhibit NK cytotoxicity directly through its ITIM (PMID: 19815499). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: T cell immunoreceptor with Ig and ITIM domains Calculated Molecular Weight: 26 kDa GenBank Accession Number: NM_173799.4 Gene Symbol: TIGIT Gene ID (NCBI): 201633 RRID: AB_3672167 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: Q495A1-1 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.