Proteintech, 98037-2-RR, Anti-Human CD141/Thrombomodulin Rabbit Recombinant Antibody

Size: 100ug The CD141/Thrombomodulin (98037-2-RR) by Proteintech is a Recombinant antibody targeting CD141/Thrombomodulin in FC applications with reactivity to human samples 98037-2-RR targets CD141/Thrombomodulin in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human peripheral blood leukocytes Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information Thrombomodulin, also known as CD141, is an endothelial cell surface glycoprotein that forms a 1:1 complex with the coagulation factor thrombin and plays an important role as a natural anticoagulant. Thrombomodulin serves to convert thrombin from a procoagulant protein into the activator for protein C. Once converted to activated protein C (APC), this protein serves as a major anticoagulant in blood (PMID: 2827310). Thrombomodulin is also located in other cells (keratinocytes, osteoblasts, macrophages,...) where it might be involved in cell differentiation or in inflammation (PMID: 9814688). In humans, thrombomodulin is encoded by the THBD gene. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia. Thrombomodulin is glycosylated and has an apparent molecular weight of 75 to 110 kDa (PMID: 1650405; 2827310). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Fusion Protein Predict reactive species Full Name: thrombomodulin Calculated Molecular Weight: 60 kDa GenBank Accession Number: NM_000361.3 Gene Symbol: THBD Gene ID (NCBI): 7056 RRID: AB_3672183 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: P07204 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.