Proteintech, 98058-1-RR, Anti-Mouse ICOSLG/B7-H2/CD275 Rabbit Recombinant Antibody

Size: 100ug The ICOSLG/B7-H2/CD275 (98058-1-RR) by Proteintech is a Recombinant antibody targeting ICOSLG/B7-H2/CD275 in FC applications with reactivity to mouse samples 98058-1-RR targets ICOSLG/B7-H2/CD275 in FC applications and shows reactivity with mouse samples. Tested Applications Positive FC detected in: mouse splenocytes Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information ICOSLG, also known as B7H2 or GL50, is a type I transmembrane glycoprotein belonging to the B7 ligand family. ICOSLG is extensively expressed on professional antigen-presenting cells including B cells, macrophages, and dendritic cells, as well as non-lymphoid cells including mesenchymal stem cells, endothelial cells, fibroblasts, and tumor cells (PMID: 33756276; 35800767). It is a specific ligand for the T-cell-specific cell surface receptor ICOS and acts as a co-stimulatory molecule (PMID: 11023515; 11007762). The interaction of ICOSLG and ICOS plays important roles in the activation, proliferation, differentiation, and cytokine production of T cells as well as in the antibody secretion from B cells during secondary immune responses (PMID: 21851236). Specification Tested Reactivity: mouse Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: icos ligand Calculated Molecular Weight: 36 kDa GenBank Accession Number: NM_015790.3 Gene Symbol: CD275 Gene ID (NCBI): 50723 RRID: AB_3672205 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: Q9JHJ8-1 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.