Proteintech, 98115-1-RR, Anti-Human TIM3 Rabbit Recombinant Antibody

Size: 100ug The TIM3 (98115-1-RR) by Proteintech is a Recombinant antibody targeting TIM3 in FC applications with reactivity to human samples 98115-1-RR targets TIM3 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: Anti-CD3/CD28 treated human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information TIM3, also known as HAVCR2, is a member of the recently discovered T cell Ig and mucin domain-containing molecule superfamily. TIM3 is a negative regulatory molecule that is important for T cell tolerance and has a crucial role in autoimmunity and T cell exhaustion during chronic viral infection (PMID: 23180819). TIM3 is expressed by T-helper type 1 (Th1) cells, macrophage, monocyte, dendritic cells, CD8+ T cell and other lymphocyte subsets. Galectin-9 is a ligand for TIM3. TIM3-galectin-9 pathway negatively regulates T helper type 1 immunity (PMID: 16286920). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant Protein Predict reactive species Full Name: hepatitis A virus cellular receptor 2 Calculated Molecular Weight: 301 aa, 33 kDa GenBank Accession Number: BC020843 Gene Symbol: TIM3 Gene ID (NCBI): 84868 RRID: AB_3672262 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: Q8TDQ0 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.