Proteintech, 98281-1-RR, Anti-Human KLRB1/CD161 Rabbit Recombinant Antibody

Size: 100ug The KLRB1/CD161 (98281-1-RR) by Proteintech is a Recombinant antibody targeting KLRB1/CD161 in FC applications with reactivity to human samples 98281-1-RR targets KLRB1/CD161 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human peripheral blood leukocytes Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information CD161, also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: killer cell lectin-like receptor subfamily B, member 1 Calculated Molecular Weight: 25 kDa GenBank Accession Number: NM_002258.3 Gene Symbol: CD161 Gene ID (NCBI): 3820 ENSEMBL Gene ID: ENSG00000111796 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: Q12918 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.