Proteintech, 98304-3-RR, Anti-Human HER2/ErbB2 Rabbit Recombinant Antibody

Size: 100ug The HER2/ErbB2 (98304-3-RR) by Proteintech is a Recombinant antibody targeting HER2/ErbB2 in FC applications with reactivity to human samples 98304-3-RR targets HER2/ErbB2 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: MCF-7 cells, Transfected CHO cells Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information HER2, also known as ErbB2, Neu, and CD340, is a 185-kDa transmembrane glycoprotein member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand-binding domain and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signaling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) Calculated Molecular Weight: 1255 aa, 138 kDa GenBank Accession Number: BC156755 Gene Symbol: HER2/ErbB2 Gene ID (NCBI): 2064 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P04626 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.