Proteintech, 98343-1-RR, Anti-Human IFNGR1/CD119 Rabbit Recombinant Antibody

Size: 100ug The IFNGR1/CD119 (98343-1-RR) by Proteintech is a Recombinant antibody targeting IFNGR1/CD119 in FC applications with reactivity to human samples 98343-1-RR targets IFNGR1/CD119 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human peripheral blood leukocytes Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information Interferon-gamam (IFN-γ) is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of two subunits, IFNGR1 (CD119) and IFNGR2. IFNGR1 is the ligand-binding subunit which binds IFN-γ with high affinity, whereas IFNGR2 serves as the accessory subunit. Two subunits bind one IFN-γ dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. (PMID: 17981204; 946248; 10888113) Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: interferon gamma receptor 1 Calculated Molecular Weight: 54 kDa GenBank Accession Number: NM_000416.3 Gene Symbol: IFNGR1 Gene ID (NCBI): 3459 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P15260-1 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.