Proteintech, 98373-3-RR, Anti-Human KIR2DL3/CD158b2 Rabbit Recombinant Antibody

Size: 100ug The KIR2DL3/CD158b2 (98373-3-RR) by Proteintech is a Recombinant antibody targeting KIR2DL3/CD158b2 in FC applications with reactivity to human samples 98373-3-RR targets KIR2DL3/CD158b2 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of inhibitory and activating receptors expressed on NK cells and a subset of T cells (PMID: 11861603). These polymorphic receptors interact with specific motifs on HLA class I molecules, modulate NK cytolytic activity and are encoded by genes located on chromosome 19q13.4 (PMID: 17069649). KIR2DL3, also known as CD158B2 or NKAT2, is an inhibitory receptor that is specific for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7) (PMID: 10196125). It is a 341-amino acid transmembrane glycoprotein consisting of an extracellular region containing two C2-type Ig-like domains, a 19-amino acid hydrophobic transmembrane region, and a long cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory motifs (ITIMs). KIR2DL3 inhibits the cytolytic activity of NK cells thus preventing cell lysis (PMID: 7724594). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 3 Calculated Molecular Weight: 38 kDa GenBank Accession Number: NM_015868.2 Gene Symbol: KIR2DL3 Gene ID (NCBI): 3804 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: P43628-1 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.