Proteintech, 98639-1-RR, Anti-Guinea Pig CD8a Rabbit Recombinant Antibody

Size: 100ug The CD8a (98639-1-RR) by Proteintech is a Recombinant antibody targeting CD8a in FC applications with reactivity to guinea pig samples 98639-1-RR targets CD8a in FC applications and shows reactivity with guinea pig samples. Tested Applications Positive FC detected in: guinea pig splenocytes Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information CD8 is a transmembrane glycoprotein composed of two disulfide-linked chains. It can be present as a homodimer of CD8α or as a heterodimer of CD8α and CD8β (PMID: 3264320; 8253791). CD8 is found on most thymocytes. The majority of class I-restricted T cells express mostly the CD8αβ heterodimer while CD8αα homodimers alone have been found on some gut intraepithelial T cells , on some T cell receptor (TCR) γδ T cells and on NK cells (PMID: 2111591; 1831127; 8420975). CD8 acts as a co-receptor that binds to MHC class-I and participates in cytotoxic T cell activation (PMID: 8499079). During T cell development, CD8 is required for positive selection of CD4-/CD8+ T cells (PMID: 1968084). Specification Tested Reactivity: guinea pig Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: CatNo: Eg7178 Product name: Recombinant guinea pig CD8A protein Source: mammalian cells -derived, V37 Tag: C-rFc Domain: 24-176 aa of NM_001172876.1 Sequence: QGASQFRMSPRELVAQVGTKVTLRCEVLVPNAPAGCSWLFQPRHDAKGPTFLLYHSASGTKLAPGLEQKRFSPSKSSNTYTLTVNSFQKRDEGYYFCSVSGNMMLYFSPFVPVFLPAPRTTTPPPPPTTPTPSVQPTSVRPETCVVSKGAAGA Predict reactive species Full Name: CD8 subunit alpha Calculated Molecular Weight: 26 kDa GenBank Accession Number: NM_001172876.1 Gene Symbol: CD8a Gene ID (NCBI): 100379570 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q6W8W8 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.