Sartorius, 98IEXS42D-L, Sartobind® S Cassette

Sartobind® S membrane adsorber units combine the advantages of convective media and ion exchange chromatography for rapid and easy contaminant removal or capture of virus and virus like particles.
The cassette design eliminates the 5 L size limitation for membrane adsorbers and offers simple pod-like modular system up to 100 L membrane volume.

Sartobind® S membrane adsorbers display a macro-porous structure with pore size of > 3 µm. Sulfonic acid ligands are bound covalently to the complete internal surface of the membrane, resulting in separation media of high binding capacity combined with exceptional high flow rates.
Applications:
The S membrane adsorber is successfully used in FDA-approved drug manufacture to remove host cell proteins at high flow rates. As a cation exchanger it displays not only aggregate removal capabilities but typically at least ten-fold higher binding capacity for viruses and virus-like-particles (VLP).
Benefits:
The Sartobind S adsorber speeds up the production process by high flow rate and opens new opportunities for the purification of therapeutic proteins and vaccines.
High speed host cell protein removal up to 30 bed volumes/ min
Aggregate removal
Easy to use:
Plug and play devices from 0.08 ml to 5 l
Can be used like a filter
Flow rate up to 30 bed volumes/min
Disposable or re-usable

Specifications
Applications:
Application: Polishing

Compliance Information:
Biological Reactivity: All materials of this filter element meet the requirements of the current USP Biological Reactivity tests <88> for plastics Class VI (Systemic Injection, Intracutaneous and Implantation tests).

Connections (Physical):
Connector(s): Sanitary 1" – 1.5" via manifold

Dimensions:
Bed Height: 4 mm
Dimensions WxDxH: 634 × 49 × 387 mm
Membrane Area: 2.9 m²

Features:
Reusable: Yes

Materials of Construction:
Housing Material: Acrylonitrile butadiene styrene (ABS)
Materials of Construction: Polyester
Membrane Material: Stabilized reinforced cellulose

Operating Conditions:
Maximum Operating Pressure: 0.2 MPa
Maximum Venting Pressure: 0.5 bar, 0.05 MPa, 7 psi
Recommended Flow Rate: 16 L/min
pH Stability: pH 3 – 14 (short term), pH 4 – 13 (long term)

Physicochemical Information:
Bed Volume: 0.8 L
Chemical Compatibility: Stable in common chromatography buffers, unstable to peroxide and other oxidizing or reactive reagents
Ligand: Sulfonic acid
Ligand Density: 2 – 5 µeq/cm²
Pore Size: 3 – 5 µm
Reference Protein: Lysozyme
Thermal Stability: Sartobind cassettes with ion exchange membranes cannot be autoclaved, but they can be gamma irradiated.
Typical Dynamic Binding Capacity 10% per unit: 23.2 g
Void Volume: 2.5 L

Product Information:
Brand: Sartobind® S
Membrane Adsorber Format: Cassettes
Membrane Type: Strong cation exchanger
Pack Size: 1
Type: Membrane adsorber
What you receive: 1 cassette; 1 operating instruction; 1 certificate