Sartorius Bioreactors & Fermenters for Scalable Cell and Microbial Production

From rapid process development to GMP manufacturing, Sartorius bioreactors and fermenters provide a scalable, PAT-ready platform for cell culture and microbial production. You can start with multi-parallel microscale screening, move to benchtop optimization, and scale confidently into single-use or stainless-steel production with consistent control of pH, DO, mixing, and gas transfer.

Applications & Use Cases for Cell Culture and Microbial Fermentation

Across biologics and industrial biotech, these systems support platform mAbs and recombinant proteins, viral vectors (AAV/lenti), CGT seed trains, and high-OTR microbial runs for pDNA, enzymes, and metabolites. The portfolio spans gentle rocking for shear-sensitive cell lines and stirred-tank performance for intensified or long campaigns, so you can choose a path that preserves viability and CQA control without slowing development.

Operating Modes: Batch, Fed-Batch & Perfusion Bioreactors

Mode selection should follow your targets for titer, COGS, and quality. The matrix below highlights the practical trade-offs so you can map the right path before scaling.

System Types: Single-Use vs Stainless-Steel Bioreactors

Your choice depends on changeover speed, validation strategy, and run length. Single-use bioreactors minimize cleaning validation and cross-contamination risk—ideal for multi-product facilities—while stainless-steel remains attractive for very large, long campaigns. Because both lines share control philosophy and PAT options, you can select by facility strategy without sacrificing process comparability.

Scale-Up Pathway: Bench → Pilot → Production

A coherent equipment ladder protects comparability (kLa, P/V, tip speed) as you move from screening to manufacturing. Ambr® 250 High Throughput (100–250 mL, 12/24 reactors) compresses DoE and clone/media mapping;

Biostat® B-DCU translates parameters at bench scale;

Biostat® RM expands shear-sensitive seeds with rocking motion;

Biostat STR® Gen 3 takes you into single-use stirred-tank production up to ~2,000 L and can integrate XCell® ATF for intensification.

Mixing, Aeration & PAT Sensors in Sartorius Bioreactors

Consistent outcomes rely on mass transfer and real-time insight. STR systems offer conventional impeller and sparger configurations with gas-mix control; RM bags provide low-shear rocking with integrated aeration. Pair hardware with BioPAT® analytics—such as capacitance biomass, inline glucose, and off-gas—and manage audit-ready data with Biobrain®/MFCS for 21 CFR Part 11 environments.

Selection Guide: Choose the Right Sartorius Bioreactor

Before requesting a quote, align biology and facility strategy.

Start with organism (mammalian vs microbial) and shear/OTR needs; set working volumes (micro/bench/seed/production); pick mode (batch, fed-batch, perfusion) and whether you’ll integrate XCell® ATF; then decide single-use vs stainless-steel based on changeover cadence and validation burden.

Document data and compliance requirements (Part 11, MES/DCS links) so software and sensors arrive “fit-for-use.”

Featured Models & Specifications (ambr®, Biostat® RM/B-DCU/STR)

Use the table as an at-a-glance anchor for volumes, families, and SKU references. Final order codes depend on controller options, utilities, and qualification.

Compatible Consumables & Upstream/Downstream Fit

Matched single-use flow paths reduce setup time and risk. Flexsafe® RM bags (2–200 L) fit Biostat RM; Flexsafe STR® bags support STR hardware up to 2,000 L and ship ready-to-use with gassing filters. Standard sterile connectors, sampling kits, and probes close the loop, while upstream media, clarification/sterile filtration, TFF, and aseptic storage integrate cleanly around the reactor.

FAQ: Bioreactors & Fermenters

1. How wide is Sartorius single-use scale?

From 100–250 mL in Ambr 250 to ~2,000 L in Biostat STR, with RM covering 2–200 L seed expansion.

2. Rocking vs stirred tanks—when to choose which?

Use RM for shear-sensitive lines and fast seed; choose STR for fed-batch/perfusion and production scalability.

3. What about data integrity and compliance?

Biobrain®/MFCS provide audit trails and Part 11-ready records, with options to integrate into plant DCS such as DeltaV®.

Get a Quote & Process Fit Review

Share your organism, target mode (batch/fed-batch/perfusion), working volumes, oxygen transfer needs, compliance level, and go-live timeline. We’ll map your seed train, recommend the right Sartorius bioreactors and consumables, and return a clear quote and lead-time based on the SKUs and configurations above. Contact Iright Now!