Sartorius Frozen Storage & Shipping for Bulk Drug Substance (−20°C to −80°C)

When your bulk drug substance (BDS), buffers, media, or cell-based materials must travel or wait at sub-zero temperatures, you need a closed, validated path from fill to thaw. This collection brings together Sartorius solutions for controlled freezing, frozen storage, and qualified cold-chain shipping so you can choose the right bag, frame, platform, and shipper—then request an accurate quote fast.

What Is Frozen Storage & Shipping (in Bioprocess)?

Bioprocess frozen storage & shipping covers the end-to-end workflow of keeping temperature-sensitive fluids safe at −20 °C to −80 °C and moving them between suites, sites, or countries without compromising sterility or product quality. At its core are single-use freezing bags (often in protective shells), controlled freeze–thaw platforms, and pre-qualified shippers with temperature logging to maintain chain of custody and compliance. Solutions like the Celsius® FT100 and FFT/FFTp pair with Celsius® Paks to standardize freezing and thawing while reducing cryoconcentration risks.

Use Cases & Temperature Bands (−20 °C vs −80 °C)

Choosing a temperature band depends on stability, hold time, and transport duration. Use the quick matrix below to match your scenario. Then fine-tune with your QA and lane data.

Product Categories: Freezing Bags, Frames & Validated Shippers

To speed selection, this collection organizes components by role in your frozen-chain.

• Single-Use Freezing Bags (Celsius® Paks) – Sterile, ready-to-use bags sized for 1 L, 2 L, 8.3 L, and 16.6 L, designed to work with controlled plate freezers. Frames, carriers, and storage modules extend handling and throughput.

• Freeze–Thaw Platforms (Celsius® FT/FFT) – The Celsius® FT100 provides controlled-rate freeze and thaw for 1–16.6 L Paks; Celsius® FFT/FFTp is a bag-in-shell system that leverages existing freezers and simplifies scale-up. 

• Validated Shippers & Modules – SSM modules store up to 100 L of frozen Paks and drop directly into pre-qualified SSM or single-unit shippers for dry-ice transport to remote sites. Flexsafe® “bag-in-shell” options round out liquid shipping at 5/10/20 L.

How to Choose: A 3-Step Freeze–Thaw Selection Guide

Before you compare product numbers, align on these three decisions; they determine freezing kinetics, handling, and documentation.

1. Medium × Temperature – Map your fluid (protein/BDS, buffer/media, cell-related) to −20 °C vs −80 °C based on stability and travel time.

2. Volume × Form Factor – Pick 2D Pak capacity (1–16.6 L) and whether you need frames, carriers, or shells for racking, stacking, and impact resistance.

3. Connectivity × Compliance – Confirm aseptic connectors/welding, venting strategy (e.g., MPC vs filter), and the validation package you require (E&L, gamma sterility, drop/transport testing).

This reduces iteration and ensures any quote reflects the configuration you’ll actually run.

Featured Models & Specs (Celsius® / Flexsafe®) — Verified SKUs

Below are representative, high-intent SKUs validated against the Sartorius eShop. Use them as starting points for quoting and internal alignment.

Freeze–Thaw Workflow: From Fill to Thaw

A consistent, well-documented workflow protects quality and simplifies tech transfer. The steps below mirror how teams run BDS lots through freezing and shipment.

• Fill (Closed): Use sterile connectors/welding and a defined venting approach (e.g., Midisart® BV filter) to minimize bioburden and ensure label traceability.
• Controlled Freeze: With FT100 or plate-freezer setups, target even heat flux to limit cryoconcentration and ice front gradients—key to batch-to-batch consistency.
• Package & Ship: Place frozen Paks into SSMs or single-unit shippers with dry-ice load plans; add temperature logging and handling SOPs for lane validation.
• Thaw & Use: Bring product back under controlled conditions for uniform thaw, then dispense through your closed manifold to the next unit operation.

Compatibility & Accessories for Seamless Integration

Most teams ask “Will this connect to our current line?” This section is your shortcut. Celsius® logistic accessories include Pak frames, carriers, SSM modules/shippers, and trolleys; Flexsafe® shells and standard shippers cover 5/10/20 L liquid shipping. On your site, link this section to Tubing & Assemblies, Liquid Storage & Shipping, Temperature/Data Loggers, Validation Services, and Palletank® pages so users can finish a build without leaving the ecosystem.

FAQs: −20 °C vs −80 °C, 2D vs 3D, Shipping Time, Reuse

1. How do I pick −20 °C vs −80 °C?

Match to molecular stability and time in transit. BDS lots and long hauls typically use −80 °C with dry ice; buffers/media often run at −20 °C.

2. Do I need a bag-in-shell?

Shells add impact resistance, stacking, and ergonomic handling. They are standard for higher volumes or when shipping to remote sites.

3. What about validation documents?

Sartorius provides sterility (gamma/ISO 11137), E&L, and transport testing documentation for relevant SKUs; shippers and shells are qualified against rigorous norms.

4. Will FT100/FFT work with my existing freezers?

FT100 is a dedicated controlled-rate system; FFT/FFTp is designed to leverage commercially available equipment for freeze–thaw.

Get a Quote or Samples — Contact Iright for Trusted Supply

Ready to scope your build? Contact Iright to request a quote or samples. Tell us your target temperature (−20 °C or −80 °C), per-batch volume, connectors/venting preference, and shipping duration. Our team validates each configuration against Sartorius documentation and verified SKUs before pricing, so you receive a dependable proposal that aligns with GMP expectations and lane requirements. Contact Iright to move from evaluation to execution with confidence.