Abcam, ab100896, Anti-GPR54 antibody

Size: 100µg
Rabbit Polyclonal GPR54 antibody. Suitable for WB and reacts with Human samples. Cited in 7 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
GPR54 also known as Kisspeptin Receptor is a G-protein coupled receptor with a molecular mass of approximately 42 kDa. Scientists typically find GPR54 expressed in the hypothalamus pituitary and gonads where it plays a mechanical role in signaling. This receptor interacts specifically with kisspeptin a peptide that binds to it and initiates a cascade of intracellular signaling events that regulate hormone release.
Biological function summary
GPR54 functions as a critical regulator of reproductive processes. When activated by its ligand kisspeptin GPR54 triggers the release of gonadotropin-releasing hormone (GnRH) from the hypothalamus. This action promotes the secretion of luteinizing hormone and follicle-stimulating hormone. Both of these hormones are necessary for normal reproductive function. It is not part of a larger complex but plays an important role in its signaling pathway independent of complex formation.
Pathways
GPR54 is integral to the hypothalamic-pituitary-gonadal (HPG) axis. This pathway helps regulate sexual maturation and reproductive cycles in mammals. GPR54 by encouraging GnRH secretion and subsequent hormone release is essential for functioning the HPG axis. Moreover it also interfaces with signaling pathways related to metabolic regulation due to its broad influence on energy balance hormones. Related proteins in these pathways include GnRH itself and downstream signaling molecules like the LH and FSH receptors.
GPR54 links strongly to conditions such as hypogonadotropic hypogonadism and disorders of puberty onset. Mutations or dysregulation in GPR54 can lead to delayed or absent puberty due to the inadequate release of GnRH. Moreover researchers have noted connections between GPR54 and the protein LH as the absence or mutation of GPR54 disrupts LH production affecting overall reproductive health. This receptor's function positions it as a potential therapeutic target for treating reproductive disorders.