Cell Signaling Technology (CST) — Trusted Antibodies & Research Reagents
Founded in 1999 by scientists at New England Biolabs (NEB), Cell Signaling Technology (CST) is a privately held life science company headquartered in Danvers, Massachusetts, USA. CST specializes in the development and manufacture of highly validated antibodies, assay kits, and reagents for studying cell signaling pathways in the context of human disease.
With over 13,500 validated products and more citations per antibody than any other supplier, CST has become the most trusted name in signaling research worldwide. Its products are used by researchers across oncology, immunology, neuroscience, epigenetics, and cell biology in academic, biotech, and pharmaceutical settings globally. CST also maintains PhosphoSitePlus®, the world's most comprehensive open-access database of protein post-translational modifications (PTMs).
CST Product Lines: Antibodies, XP® mAbs, ChIP & ELISA Kits
CST offers a broad portfolio of research tools designed to support the full range of cell signaling experiments. Key product categories include:
Primary Antibodies CST's core offering covers over 13,500 rigorously validated primary antibodies targeting proteins involved in key signaling pathways. Available in polyclonal, monoclonal, and XP® (Extra Performance) rabbit monoclonal formats, these antibodies are validated for Western blotting (WB), immunohistochemistry (IHC), immunofluorescence (IF), immunoprecipitation (IP), and flow cytometry (FC).
XP® Rabbit Monoclonal Antibodies CST's flagship XP® series delivers exceptional sensitivity, specificity, and lot-to-lot consistency. These high-performance rabbit monoclonals are engineered for demanding applications and are among the most cited antibodies in the scientific literature.
SimpleChIP® Kits The SimpleChIP® product line provides complete chromatin immunoprecipitation (ChIP) kits using either enzymatic digestion or sonication-based chromatin fragmentation. All kits include validated controls and are compatible with ChIP-seq workflows.
PathScan® ELISA Kits PathScan® sandwich ELISA kits are designed for sensitive detection of endogenous signaling proteins, cytokines, and growth factors. They are particularly suited for studying pathway activation states without the need for Western blotting.
Secondary Antibodies & Companion Reagents CST offers 70+ secondary antibodies alongside a full range of detection reagents, buffers, and experimental controls — all optimized for use with CST primary antibodies across major applications.
Sampler Kits With over 300 pathway-focused sampler kits, CST provides an economical way to evaluate multiple antibodies within a specific signaling cascade simultaneously.
Popular CST Products & Frequently Ordered Catalog Numbers
The table below lists frequently ordered CST products across antibodies and kits. Contact Iright to request pricing and availability for any catalog number listed — or for products not shown here.
| Cat. # | Product Name | Application | Target / Notes |
|---|---|---|---|
| 4060S | Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb | WB, IHC, IF, IP, FC | Akt — most cited antibody in CST's portfolio |
| 9661S | Cleaved Caspase-3 (Asp175) Antibody | WB, IHC, IF, FC | Caspase-3 (apoptosis marker) |
| 4695S | Akt (pan) (C67E7) Rabbit mAb | WB, IP, IHC | Total Akt |
| 9102S | p44/42 MAPK (Erk1/2) Antibody | WB, IHC, IF | Total ERK1/2 |
| 4370S | Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) XP® Rabbit mAb | WB, IHC, IF, FC | p-ERK1/2 |
| 3868S | β-Actin (8H10D10) Mouse mAb | WB | Loading control |
| 8954S | Phosphotyrosine (P-Tyr-1000) Rabbit mAb | WB, IP | Pan-phosphotyrosine |
| 4267S | Phospho-p70 S6 Kinase (Thr389) (108D2) Rabbit mAb | WB, IHC | mTOR pathway |
| 9003S | SimpleChIP® Enzymatic Chromatin IP Kit (Magnetic Beads) | ChIP, ChIP-seq | Up to 30 IPs per kit |
| 9005S | SimpleChIP® Plus Enzymatic Chromatin IP Kit (Magnetic Beads) | ChIP, ChIP-seq | Optimized for cells & tissue |
Application abbreviations: WB = Western Blotting · IHC = Immunohistochemistry · IF = Immunofluorescence · IP = Immunoprecipitation · FC = Flow Cytometry
Buy CST Reagents Through Iright — Global Lab Supply
Iright is a global lab supply sourcing platform helping research institutions, distributors, and procurement teams access products from leading life science brands — including Cell Signaling Technology.
Whether you need a single catalog item or recurring bulk supply, Iright provides:
- Competitive pricing on CST antibodies, kits, and reagents
- Authentic products with full documentation and lot traceability
- Fast response to quote requests across multiple regions
- Flexible sourcing for items not readily available through local distributors
Iright serves customers across North America, Europe, the Middle East, Central Asia, and Latin America, and functions as a reliable backup sourcing contact for labs with existing CST supply chains.