Abcam, ab1037, Anti-Hepatitis G Virus antibody

Size: 50µg
Rabbit Polyclonal Hepatitis G Virus antibody. Suitable for WB and reacts with GB virus C samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:Unknown,
Light chain type:unknown,
Carrier free:No,
Reacts with:GB virus C,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This antibody recognizes the NS5 polyprotein of HGV, also known as GBV-C/HBV.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Hepatitis G Virus (HGV) also known as GBV-C is a flavivirus with a single-stranded RNA genome. It has a genome mass of approximately 9.3 kilobases. HGV primarily targets liver tissue and can be expressed in peripheral blood mononuclear cells. The virus belongs to the Flaviviridae family and shares similarities with other hepatitis viruses such as Hepatitis C virus (HCV) but with distinct genetic properties that set it apart in its mechanical structure and infectious process.
Biological function summary
HGV functions through interactions with various cellular receptors and proteins to establish infection in the host. It does not form part of a well-defined protein complex itself but influences the host’s immune response. HGV is known for its potential modulatory effects on the immune system which might inhibit the replication of other viruses especially in co-infection scenarios.
Pathways
Scientists have identified that mechanisms of HGV can impact immune signaling pathways. One important pathway is the inhibition of HIV replication where HGV might interact with cellular proteins to modulate immune responses. HGV's potential relationship with immunomodulatory proteins suggests it might affect pathways similar to those influenced by immune checkpoints or cytokine signaling.
HGV is associated with chronic hepatitis infections although it is less pathogenic compared to other hepatitis viruses. Some studies suggest a correlation between HGV infection and a reduced progression of HIV in co-infected individuals. During co-infection proteins from HGV and HIV could engage in interactions that might slow HIV disease progression presenting a unique area for therapeutic exploration.