Abcam, ab105025, Anti-NDUFS7 antibody

Size: 200µL
Goat Polyclonal NDUFS7 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial aa 50-100.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial aa 50-100. The exact immunogen used to generate this antibody is proprietary information.O75251

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab105025 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NDUFS7 also known as NADH:ubiquinone oxidoreductase subunit S7 plays an important role in complex I of the mitochondrial respiratory chain. This protein with a mass of about 21 kDa is expressed in tissues with high energy demands such as heart brain and skeletal muscle. NDUFS7 contributes to the electron transport pathway by facilitating the transfer of electrons from NADH to ubiquinone.
Biological function summary
NDUFS7 becomes a functional component through its participation in the mitochondrial complex I. This large multi-subunit complex is essential for ATP production and consists of 45 subunits. NDUFS7 along with other subunits like NDUFS1 and NDUFS2 ensures the proper assembly and function of this complex. It influences oxidative phosphorylation which is important for cellular energy homeostasis.
Pathways
You will find NDUFS7 incorporated within the oxidative phosphorylation and the tricarboxylic acid (TCA) cycle pathways. NDUFS7 associates closely with other complex I proteins such as NDUFA9 and NDUFB8 impacting the electron transport chain's efficiency. This cooperation supports the ATP synthesis that cells utilize for maintaining metabolic balance.
Mutations in NDUFS7 have associations with mitochondrial diseases like Leigh syndrome and neurodegenerative disorders such as Alzheimer's disease. In Leigh syndrome NDUFS7 alongside other complex I components like NDUFV1 can impair proper mitochondrial functioning leading to severe neurological symptoms. In Alzheimer's disease alterations affecting NDUFS7 might contribute to disrupted energy metabolism suggesting potential therapeutic target opportunities for these conditions.