Abcam, ab105351, Anti-ATP11A antibody

Size: 100µg
Rabbit Polyclonal ATP11A antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ATP11A.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ATP11A. The exact immunogen used to generate this antibody is proprietary information.P98196,
Specificity:ab105351 is predicted to not cross react with AT11B. At least two isoforms of ATP11A are known to exist; this antibody will recognize both.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ATP11A also known as AtpIH is a phospholipid-transporting ATPase located on the plasma membrane important for maintaining phospholipid asymmetry. Its approximate molecular weight is 130 kDa. This enzyme primarily expresses in tissues such as the brain testis and heart highlighting its important functions in these areas. ATP11A works in the flipping of aminophospholipids from the outer to the inner leaflet of cellular membranes playing an important role in maintaining membrane stability and function.
Biological function summary
ATP11A and its activity contribute to cellular processes including vesicle formation and transport across the membrane. It often functions as a part of a larger protein complex which facilitates its phospholipid translocating action. By coordinating with specific binding partners ATP11A supports cellular morphology and communication ultimately assisting in developmental and functional processes in several tissues.
Pathways
ATP11A participates significantly in the phospholipid transport pathway and cellular homeostasis. It closely interacts with CDC50 proteins such as CDC50A which act as regulatory subunits assisting in the flipping activity. On a broader scale ATP11A influences membrane trafficking pathways and the asymmetry of phospholipids linking it to key cellular events like apoptosis and immune response. These interactions enhance the precision and efficiency of its role in cellular function.
Disrupted ATP11A function associates with immune disorders and neurological conditions. Aberrations in its normal activity can lead to immune system dysfunctions and specific types of neuropathies. The dysregulation of ATP11A also links it to Alzheimer's disease where improper membrane phospholipid distribution might influence neurodegenerative processes. Understanding the interaction between ATP11A and related proteins like APP (amyloid precursor protein) aids in clarifying its role in these disorders.