Abcam, ab105407, Anti-NLRP10 antibody

Size: 100µg
Rabbit Polyclonal NLRP10 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human NLRP10.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NLRP10. The exact immunogen used to generate this antibody is proprietary information.Q86W26,
Specificity:At least two isoforms of NLRP10 are known to exist; this antibody will recognize both. The antibody is predicted to not cross-react with other NLRP family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The NLRP10 protein also known as NALP10 or PYNOD plays a significant role in the immune system. NLRP10 has a molecular mass of approximately 81 kDa and belongs to the nucleotide-binding domain leucine-rich repeat (NLR) family. It is expressed predominantly in immune cells such as macrophages and dendritic cells. Structurally NLRP10 lacks the pyrin domain that is common to other members of its family which influences its function.
Biological function summary
NLRP10 modulates inflammatory responses and immune cell activity. It functions as part of the innate immune system and is linked to the regulation of inflammasomes. NLRP10 is also connected with dendritic cell migration influencing the immune response to pathogens. By controlling cytokine release it plays a role in mitigating excessive inflammation.
Pathways
NLRP10 integrates into the inflammatory signaling processes. It impacts the NF-κB signaling pathway an important regulator of immune response. Where the pathway involves inflammasomes NLRP10 interacts with other NLR family members like NLRP3. These interactions modulate immune responses through complex pathways affecting how cells respond to infections.
NLRP10 is linked to autoimmune conditions and allergies. In autoimmune diseases such as lupus the regulatory role of NLRP10 influences the immune system’s tolerance to self-antigens. In allergic conditions it modulates the inflammatory response and cytokine release. There are connections with proteins like NLRP3 in these disorders where both play roles in the immune system's regulation and inflammation control.