Abcam, ab107572, Anti-DECTIN 2 antibody [IMG3D1]

Size: 100µg
Mouse Monoclonal DECTIN 2 antibody. Suitable for Flow Cyt, WB, IHC-P, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human CLEC6A aa 50-150.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:IMG3D1,
Isotype:IgG3,
Light chain type:kappa,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:Flow Cyt, Flow Cyt (Intra), WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human CLEC6A aa 50-150. The exact immunogen used to generate this antibody is proprietary information.Q6EIG7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-Up to 6 months, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
DECTIN-2 also known as C-type lectin domain family 6 member A (CLEC6A) is a cell surface receptor that belongs to the C-type lectin family. It plays a significant role in the immune system by recognizing and binding to polysaccharides found on the surface of fungi such as alpha-mannans. DECTIN-2 is a type II transmembrane protein with an approximate molecular mass of 28 kDa. It is expressed mostly in dendritic cells and macrophages where it helps initiate immune responses against fungal pathogens.
Biological function summary
DECTIN-2 is a part of the innate immune system functioning through its association with the Fc receptor gamma chain to form a signaling complex. This interaction allows DECTIN-2 to transmit signals that lead to the activation of the NF-kB pathway which in turn stimulates the production of pro-inflammatory cytokines. The role of DECTIN-2 extends to influencing adaptive immunity as it helps in the maturation of dendritic cells and the proliferation of antigen-specific T cells.
Pathways
The DECTIN-2-mediated signaling integrates into the broader pattern recognition receptor pathways notably the C-type lectin receptor signaling pathway and the complement cascade. DECTIN-2 interacts closely with other proteins like DECTIN-1 another C-type lectin and complement protein C3 which together coordinate a more comprehensive immune response. These interactions enhance pathogen recognition and clearance emphasizing DECTIN-2's important position within the immune surveillance system.
DECTIN-2 is particularly relevant in conditions such as fungal infections and autoimmune diseases. In fungal infections DECTIN-2 together with DECTIN-1 enhances the body's ability to detect and respond to pathogenic fungi reducing infection severity. Additionally abnormal DECTIN-2 signaling or expression may contribute to autoimmune disorders such as rheumatoid arthritis where overactive immune responses cause tissue damage. Understanding DECTIN-2's role could provide insight into potential therapeutic targets for managing these diseases.