Abcam, ab10873, Anti-Cdc13 antibody [6F11/2]

Size: 50µg
Mouse Monoclonal CG23 antibody. Suitable for WB and reacts with Schizosaccharomyces pombe samples. Cited in 8 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:6F11/2,
Isotype:IgG2a,
Carrier free:No,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Product details:
Cdc13 is a fission yeast (S. pombe) B-type M-phase cyclin. Cdc13 binds to Cdk1 (cdc2), and the resulting Cdk1-Cdc13 complex controls the G2/M transition of the cell cycle. 6F11/2 can be used for detecting Cdc13 and associated Cdk1 kinase activation.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cdc13 also known as Cell division cycle 13 is a telomere-binding protein and its mass is approximately 1353 amino acids. The target is expressed in yeast cells. It serves as a component of the telomeric cap structure effectively maintaining the integrity and stability of chromosome ends. Cdc13 plays a pivotal role in ensuring proper telomere length regulation and protection against degradation or fusion.
Biological function summary
Cdc13 interacts with telomerase forming part of an important complex that safeguards telomeres. This protein helps recruit telomerase to telomeres facilitating telomere maintenance during DNA replication. Through its association with other proteins like Stn1 and Ten1 Cdc13 is key in regulating telomere elongation and preventing unscheduled telomere extension.
Pathways
Cdc13 acts importantly within the telomere maintenance pathway contributing to genome stability. The protein intimately interacts within the telomerase complex comprising proteins like Est1 and Est3 ensuring the proper execution of telomerase-mediated telomere synthesis. Cdc13 influences the pathway of DNA damage response by potentially controlling telomere length and structure therefore aiding in cell cycle progression and cellular proliferation.
Cdc13's function affects genomic instability which is connected to cancer and aging-related disorders. Disruptions in Cdc13-mediated telomere maintenance can lead to telomere defects similarities to certain cancer types and premature senescence. Its role in safeguarding telomere integrity parallels the function of mammalian TRF2 protein which further emphasizes the link between telomere dysfunction Cdc13 and related conditions.