Abcam, ab109407, Anti-PTCHD1 antibody

Size: 200µL
Goat Polyclonal PTCHD1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human PTCHD1 aa 250-300.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PTCHD1 aa 250-300. The exact immunogen used to generate this antibody is proprietary information.Q96NR3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab109407 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PTCHD1 also known as Patched domain-containing protein 1 is a protein with a mass of approximately 139 kDa. This protein functions as a receptor that interacts with and regulates the Hedgehog signaling pathway. PTCHD1 is widely expressed in the human brain particularly in both neuronal and glial cells. This expression pattern suggests a significant role in neural development and function. The protein structure includes a large extracellular domain allowing it to bind with various ligands associated with cell signaling processes.
Biological function summary
PTCHD1 plays an important role in modulating the Hedgehog signaling pathway which is essential for cell differentiation and growth. This protein is thought to work as a part of a complex involving the regulation of cell membrane-associated signaling proteins. Its presence ensures correct signaling dynamics influencing cellular processes such as proliferation and tissue patterning during development. PTCHD1's function highlights its potential impact on the proper organization and operation of the neural environments.
Pathways
PTCHD1 is significantly involved in the Hedgehog signaling and its regulation. This pathway is important for embryonic development and various postnatal processes. PTCHD1 interacts with other proteins in this pathway such as Smoothened (SMO) and the GLI family of transcription factors coordinating the transmission of signals that govern cellular fate decisions. Through these interactions PTCHD1 influences processes from growth and differentiation to apoptosis.
Alterations in PTCHD1 expression or function relate to neurodevelopmental disorders such as autism spectrum disorders (ASD) and intellectual disabilities. Studies have shown that PTCHD1 mutations can disrupt normal Hedgehog signaling influencing brain development and function. Additionally PTCHD1's interaction with other proteins like SHANK3 highlights its significance in maintaining synaptic integrity and function further associating it with ASD and related conditions. Understanding these connections can aid in developing targeted therapies for these complex disorders.