Abcam, ab109495, Anti-Somatostatin Receptor 5 antibody [UMB4]

Size: 20µL / 100µL / 1mL
Anti-Somatostatin Receptor 5 antibody [UMB4] (ab109495) is a rabbit monoclonal antibody detecting Somatostatin Receptor 5 in Western Blot, IHC-P . Suitable for Human . - Biophysical QC for unrivalled batch-batch consistency - Over 40 publications
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:UMB4,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Internal WB test in PANC-1, human pancreas and human brain lysates indicates this antibody might not detect endogenous Somatostatin Receptor 5.

Product details:
What is this antibody validated in?
Anti-Somatostatin Receptor 5 antibody [UMB4] (ab109495) is a rabbit recombinant monoclonal antibody and is validated for use in Western Blot (WB), Immunohistochemistry (IHC-P) in Human samples.
What is the molecular weight of Somatostatin Receptor 5?
Anti-Somatostatin Receptor 5 [UMB4] (ab109495) specifically detects a band for Somatostatin Receptor 5 (UniProt: P35346) at a molecular weight of 39kDa.
Trusted by the scientific community
Anti-Somatostatin Receptor 5 [UMB4] (ab109495) was first used in a scientific publication in 2011 and has been cited over 40 times in peer-reviewed journals.
Trial sizes available!
Test your antibody or perform pre-screening before committing to a larger quantity. Sold in 10µl.
Discover our selection of trial-size antibodies
Other related products
We have a range of other formats of antibody clone [UMB4] also available for your convenience: ab109495, Carrier free -
ab236074
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Stable for 12 months at -20°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Somatostatin Receptor 5 also known as SSTR5 is a G protein-coupled receptor with a molecular weight of approximately 61 kDa. Mechanically SSTR5 couples with G proteins to inhibit adenylyl cyclase activity leading to reduced cAMP levels. This receptor is expressed in different tissues including the brain pituitary gland and pancreas reflecting its diverse physiological roles. SSTR5 exhibits a distinct expression pattern compared to other somatostatin receptors providing a unique contribution to tissue-specific functions.
Biological function summary
The Somatostatin Receptor 5 regulates hormone secretion and cell proliferation. SSTR5 is not a part of a larger protein complex but it interacts with molecules such as somatostatin which is a peptide hormone that inhibits the release of several other hormones. Through these interactions SSTR5 helps control endocrine and exocrine secretions. Its role in modulating cell growth makes it an important factor in maintaining tissue homeostasis and influencing cell signaling processes.
Pathways
Somatostatin Receptor 5 is involved in the cAMP signaling pathway and the MAPK/ERK pathway. In the cAMP signaling pathway SSTR5 helps mediate the inhibitory effects on adenylyl cyclase while in the MAPK/ERK pathway it influences cell proliferation and differentiation. Related proteins in these pathways include other somatostatin receptors like SSTR2 with which SSTR5 might share regulatory effects on inhibitory processes. These pathways highlight the receptor's role in integrating multiple signaling cascades affecting both cellular metabolism and growth.
Somatostatin Receptor 5 is associated with growth hormone-related disorders such as acromegaly and certain types of cancer like pancreatic cancer. In acromegaly SSTR5 alongside SSTR2 impacts the pathological overproduction of growth hormone due to its expression in pituitary adenomas. In pancreatic cancer an altered expression of SSTR5 can influence tumor progression due to its regulatory effects on cell proliferation pathways. Understanding SSTR5's interaction with these diseases helps in developing therapeutic strategies targeting its specific signaling functions.