Abcam, ab109984, Anti-Npas4 antibody

Size: 200µL
Goat Polyclonal NPAS4 antibody. Suitable for WB and reacts with Mouse, Human, Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human NPAS4 aa 100-200.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human NPAS4 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.Q8IUM7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide., Storage buffer-pH: 7.3Preservative: 0.02% Sodium azideConstituents: 99% Tris buffered saline, 0.5% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Npas4 also known as Neuronal PAS domain protein 4 functions mechanically as a transcription factor. It weighs approximately 88 kDa. Scientists find Npas4 expression primarily in the brain particularly in regions involved with learning and memory processes. This protein plays an important role in regulating the expression of other genes especially in neurons.
Biological function summary
Npas4 modulates the response of neurons to activity. It is not part of a larger complex but interacts with various partners to achieve its function. Npas4 activates specific gene programs that control synaptic plasticity supporting the strengthening or weakening of synapses. This helps maintain excitatory-inhibitory balance in neural circuits a critical process for proper brain function.
Pathways
Researchers find Npas4's role integral in the signaling cascades involved in synaptic plasticity and experience-dependent neuronal development. It works closely with pathways like calcium signaling where Npas4 acts in response to changes in calcium levels to alter gene expression. The BDNF protein known for its role in neuronal growth is significantly influenced by Npas4 activity in these pathways highlighting its importance in neural adaptation.
Npas4 shows a connection to mental health conditions. Impaired Npas4 function relates to anxiety disorders where altered synaptic plasticity plays an important role. Additionally its dysregulation has links to neurological disorders like epilepsy due to its part in maintaining synaptic balance. Aberrant Npas4 expression influences these disorders and often involves interactions with GABAergic signaling pathway proteins affecting the overall excitatory and inhibitory dynamics in neuronal networks.