Abcam, ab110056, Anti-JP-2 antibody

Size: 50µg
Rabbit Polyclonal JP-2 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human JPH2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human JPH2. The exact immunogen used to generate this antibody is proprietary information.Q9BR39,
Specificity:Multiple isoforms of JPH2 are known to exist.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Junctophilin 2 (JP-2) is a protein that plays an important role in the formation of junctional membrane complexes. It belongs to the junctophilin family and has a mass of approximately 65 kDa. JP-2 is expressed in cardiac and skeletal muscle tissues where it facilitates close connections between the plasma membrane and the sarcoplasmic reticulum. These connections are essential for efficient calcium signaling which is integral to muscle contraction and function.
Biological function summary
JP-2 contributes to the structural bridge between transverse tubules (T-tubules) and the sarcoplasmic reticulum. It is a critical component of the excitation-contraction coupling machinery in muscle cells. JP-2 works as part of a larger protein complex that includes ryanodine receptors and dihydropyridine receptors. These complexes ensure precise delivery and regulation of calcium ions critical to muscle cell contraction.
Pathways
Junctophilin 2 is closely linked within the calcium signaling and muscle contraction pathways. It partners with proteins like the ryanodine receptor (RyR) and the L-type calcium channel both of which are indispensable for calcium ion movement across the muscle cell membranes. JP-2's interaction with these pathways highlights its role in maintaining calcium homeostasis required for muscle function.
Junctophilin 2 contributes to conditions such as hypertrophic cardiomyopathy and heart failure. Mutations or dysregulation of JP-2 can disrupt normal calcium signaling and lead to these heart disorders. In the context of hypertrophic cardiomyopathy its disruption affects proteins like the ryanodine receptor indicating its pivotal place in both disease development and potential therapeutic targeting.