Abcam, ab110227, Anti-HSV1 gH antibody [BBH1]

Size: 100µg
Mouse Monoclonal GH antibody. Suitable for WB, IP, ICC/IF, IHC-P and reacts with Transfected cell lysate - Herpes simplex virus, Transfected cell line - Herpes simplex virus samples. Cited in 5 publications.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:BBH1,
Isotype:IgG2a,
Carrier free:No,
Reacts with:Herpes simplex virus,
Applications:IHC-P, IP, ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:Cross-reactivity has not been checked and this antibody might cross with HSV-2 gH.

Product details:
This product has switched from a hybridoma to recombinant production method on 27th October 2023.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HSV1 gH also known as glycoprotein H is a significant component of the Herpes Simplex Virus type 1 (HSV-1). The glycoprotein has a molecular mass of approximately 93 kDa and is expressed on the viral envelope. It plays a vital role in the virus's ability to infect host cells. Glycoprotein H functions by facilitating the fusion of the viral envelope with the host cell membrane a critical step for viral entry. Besides its primary expression in HSV-1 this protein shares similarities with entry proteins in other herpesviruses indicating its conserved role across different species.
Biological function summary
Glycoprotein H functions as part of the glycoprotein H-L complex which includes glycoproteins H L and D. This complex orchestrates the fusion process necessary for the virus to penetrate and infect host cells. The glycoprotein H is vital for the stabilization of the complex and contributes to the proper implementation of viral infection processes. Distribution of this protein in the host organism occurs predominantly in epithelial cells which often serve as the initial site of infection. This distribution aids in the rapid spread of the virus within the host.
Pathways
Glycoprotein H is important for the viral entry pathway. The entry involves interactions with host cell surface receptors that mediate viral attachment and fusion. This process places glycoprotein H within the larger context of viral lifecycle pathways interlinked with proteins such as glycoprotein B and glycoprotein D which assist in initial viral attachment and binding to host cells. The coordination among these proteins ensures efficient viral penetration and subsequent replication within the host.
HSV1 gH has a direct connection to herpes simplex infections particularly oral and genital herpes. Its role in viral entry makes it a target for therapeutic interventions aimed at preventing herpesvirus infections. Antibodies targeting glycoprotein H and related viral components can serve as potential treatments by inhibiting virus attachment and entry. Given its role in immune recognition interactions between glycoprotein H and immune cells provide insights into the development of strategies against viral persistence and reactivation particularly in individuals with compromised immune systems.